Small Molecule DMPK / Bioanalysis Scientist

Open to Sr. RA $35-45/hr OR scientist $50-62/hr

Job Description

This role focuses on hands-on small molecule bioanalysis within a nimble drug metabolism and pharmacokinetics (DMPK) environment. The contractor supports end-to-end bioanalytical workflows, including tissue and plasma sample preparation, LC‑MS/MS methods, and pharmacokinetic and pharmacometric analyses. The position suits someone who enjoys working at the bench, can quickly integrate into a collaborative team, and operates independently with minimal guidance while contributing across the full DMPK workflow.

Responsibilities

• Perform hands-on tissue and plasma sample preparation to support small molecule bioanalysis, ensuring accurate handling, labeling, and tracking of all samples.
• Prepare and execute calibration curves and dilutions to support robust LC‑MS/MS quantitation of small molecules.
• Conduct sample thawing and processing activities in accordance with established bioanalytical protocols and quality standards.
• Support and execute LC‑MS/MS workflows for small molecule bioanalysis, including instrument setup, basic troubleshooting, and routine operation.
• Contribute to pharmacokinetic and pharmacometric (PK/PD) analyses using tools such as NONMEM and PsN, supporting data analysis and interpretation.
• Perform plasma protein binding assays and related in vitro studies as needed to support small molecule characterization.
• Support microsomal and other in vitro ADME assays as required, contributing to broader DMPK and bioanalysis studies.
• Work across the full DMPK workflow with limited handholding, taking ownership of assigned experiments and tasks from planning through execution and documentation.
• Collaborate closely with a small, nimble DMPK team to prioritize tasks, troubleshoot issues, and ensure timely delivery of high-quality data.
• Document experimental procedures, results, and observations clearly and accurately in laboratory records and reports.
• Follow laboratory best practices, standard operating procedures, and safety guidelines while maintaining a clean and organized work area.
• Contribute proactively to process improvements and workflow optimization within the DMPK and bioanalysis function.

Essential Skills

• Hands-on experience in small molecule bioanalysis within a DMPK or related laboratory environment.
• Strong background in bioanalysis, including tissue and plasma sample preparation and handling.
• Proficiency with LC‑MS/MS workflows for quantitative analysis of small molecules.
• Demonstrated ability to prepare calibration curves and perform accurate dilutions for bioanalytical assays.
• Experience with sample thawing, processing, and management in a regulated or process-driven laboratory setting.
• Practical experience with pharmacokinetic and pharmacometric analysis tools such as NONMEM and PsN.
• Ability to support the full DMPK workflow from sample preparation through data generation with limited supervision.
• Capability to operate independently, take initiative, and manage multiple tasks in a fast-paced environment.
• Strong documentation skills and attention to detail in recording experimental procedures and results.
• Excellent collaboration and communication skills to work effectively within a small, cross-functional team.

Additional Skills & Qualifications

• Experience with plasma protein binding assays to characterize small molecule binding properties.
• Experience with microsomal assays and other in vitro ADME studies.
• Broader ADME and DMPK experience beyond core bioanalysis responsibilities.
• PhD in a relevant scientific discipline (such as pharmacology, pharmaceutical sciences, chemistry, or a related field).
• Postdoctoral experience in DMPK, bioanalysis, or a closely related area.
• Familiarity with additional DMPK tools, software, and workflows is advantageous.
• Interest in gaining comprehensive exposure to end-to-end DMPK workflows within a dynamic team environment.

Work Environment

The role is based within a nimble DMPK team in a laboratory setting in South San Francisco. The environment is highly hands-on and collaborative, with a strong emphasis on flexibility and willingness to support multiple parts of the DMPK and bioanalysis workflow. You will work closely with a small group of scientists who value open communication, shared problem-solving, and direct contributions to project progress. The position offers the opportunity to gain extensive, practical experience across the full DMPK workflow, inc