**General Description:** The Senior Manager, Clinical Site Payment Portfolio Management is responsible for global financial oversight, reconciliation, and portfolio-level governance of investigator grant payments across BeOne-sponsored clinical trials. This role partners closely with the Director of Clinical Site Payments, Head of CBO, Regional Clinical Site Payments teams, R&D Finance, Global R&D Sourcing (GRDS), payment vendors, and cross-functional stakeholders to ensure accurate financial reporting, accrual integrity, and compliance with SOX and internal control frameworks. This position serves as a critical interface between Clinical Operations and Finance, responsible for end-to-end management of investigator grant financials, including monthly reconciliation, accrual accuracy, Budget vs. Actuals (BvA) tracking, and forward-looking financial forecasts. The role also owns Clinical Site Payment portfolio metrics, reporting, and analytics dashboards, and ensures alignment of payments data with approved budgets, negotiated contracts, and the Clinical Payment taxonomy (CPT codes, CTP categories, subcategories) in accordance with the CPP Library framework. **1. Portfolio Financial Oversight & Reconciliation** + Lead monthly reconciliation of global investigator grant expenses, ensuring alignment across site payments, vendor disbursements, and financial ledgers + Review and validate payment vendor drawdowns, ensuring appropriate funding levels and supporting documentation + Partner with Regional Clinical Site Payments teams and vendors to investigate discrepancies and drive timely resolution + Maintain a consolidated portfolio view of payments, accruals, commitments, and outstanding liabilities **2. Purchase Order (PO) & Financial Lifecycle Management** + Oversee creation, maintenance, and lifecycle management of Purchase Requisitions (PRs) and Purchase Orders (POs) for clinical site payments and vendors + Ensure POs accurately reflect study budgets, amendments, and forecasted spend + Monitor PO balances, utilization, and close-out activities to support financial accuracy and audit readiness + Manage vendor invoice review, validation, and approvals in collaboration with GRDS and R&D Finance **3. Accruals, Close Process & BvA Analysis** + Own monthly PO accrual analysis and reporting in partnership with R&D Finance and GRDS + Ensure accurate and timely investigator grant accruals in compliance with financial close timelines and SOX requirements + Perform Budget vs. Actuals analysis at study and portfolio level, identifying key variances, trends, and financial risks + Partner with R&D Finance and Treasury to support financial close activities and ensure completeness of recorded expenses **4. Clinical Site Financial Closeout & Unbilled Liability Forecasting** + Develop deep understanding of site-level financial closeout processes to ensure completeness of final investigator grant expenses + Partner with GRDS and R&D Finance to identify and project outstanding expenses incurred but not yet invoiced by sites + Ensure accrual coverage for unbilled costs through closeout periods and study transitions + Support accurate financial representation of liabilities across the clinical portfolio **5. Financial Modeling, Forecasting & Scenario Analysis (Critical Capability)** + Develop and maintain financial models to support: + Accrual forecasting and cash flow projections + Scenario analysis (e.g., enrollment changes, study delays, vendor mix, FX rate impacts) + Internalization strategies for clinical payments + Lead **short-term and long-term forecasting** for internalized countries in partnership with R&D Finance and Treasury + Analyze impact of business and operational changes on financial performance and portfolio risk **6. Data Alignment, Reporting & Payment Analytics** + Own Clinical Site Payment KPIs, metrics framework, and reporting cadence + Develop and maintain analytics dashboards (e.g., Power BI) to monitor: + Payment cycle times + Accrual vs. actual accuracy + Forecast deviations + Vendor performance and financial trends + Partner with: + CBO Budget Planning & Strategy + Clinical Site Contracts + Clinical Site Data Hub to ensure: + Payments are aligned with approved budgets and negotiated contract terms + Payment data is accurately mapped to CPT codes, categories, and subcategories + Consistency with the CPP Library data structure across reporting systems + Drive data integrity, standardization, and alignment across systems and stakeholders **7. Cross-Functional Partnership** + Act as primary liaison between Clinical Site Payments, R&D Finance, and Treasury for investigator grant financial management + Collaborate with Global Clinical Operations and R&D Finance on budget assumptions and financial tracking methodologies + Support strategic initiatives and project execution, including payment internalization and process optimization **8. Governance, Controls