Rezolute is a late-stage rare disease company focused on significantly improving outcomes for individuals with hypoglycemia caused by hyperinsulinism (HI). Our antibody therapy, RZ358 (ersodetug), is designed to treat all forms of HI and has shown substantial benefit in clinical trials and real-world use for the treatment of congenital hyperinsulinism (cHI) and tumor hyperinsulinism (tHI)

The Director Program Manager will be a key member of the Program Management Office (PMO), responsible for Launch execution plan for the company’s first rare disease drug launch. This individual will partner closely with key stakeholders and executives from Commercial, Medical Affairs, Regulatory, Manufacturing, Supply Chain to ensure operational readiness and alignment on critical path deliverables.

This role requires a proactive leader with exceptional organizational skills, strategic thinking, and the ability to influence without direct authority in a fast-paced, evolving environment.

Location: Redwood City California (in office role with travel as needed)

• Bachelor’s degree required; advanced degree (MBA, MS) preferred.
• 8+ years of experience in program or project management in the biopharmaceutical industry, with at least 3 years leading or supporting a commercial launch and/or pre-commercial readiness activity in rare disease.
• Demonstrated familiarity / working knowledge of key commercialization functions in conduct of a rare disease product launch; Experience in rare disease, specialty products, or first-launch environments strongly preferred.
• Demonstrated ability to manage complex, cross-functional projects and align diverse stakeholders.
• Strong understanding of commercialization processes and timelines in the life sciences industry.
• Excellent organizational, communication, and presentation skills.
• Proficiency with project management tools (e.g., Smartsheet, MS Project) and collaboration platforms.
• PMP or related certification a plus.

Key Competencies

• Strategic and structured problem solver with strong critical thinking.
• Highly collaborative and able to influence without authority.
• Able to thrive in ambiguity and adapt quickly to changing priorities.
• Results-driven with a sense of urgency and accountability.
• Strong interpersonal and relationship-building skills.

Rezolute (RZLT) currently anticipates the base salary for the Director Program Manager role could range from $240,000 to $290,000 and will depend, in part, on the successful candidate’s geographical location and their qualifications for the role, including education and experience. This position will also be eligible for an annual performance bonus in accordance with the terms of the applicable plan (depending, in part, on company and individual performance and at the Company’s discretion on an individual basis). The compensation described above is subject to change and could be higher or lower than the range described based on current market survey data and the qualifications, education, experience, and geographical location of the selected candidat